PU.1-IN-1
PU.1-IN-1 is a potent PU.1 inhibitor with an IC50 of 2 nM. PU.1-IN-1 reduces rMANF-induced miR-223 expression. PU.1-IN-1 exhibits anti-inflammatory properties[1][2].
Product Specifications
CAS Number
[873588-27-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MicroRNA
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pu-1-in-1.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(C2CCCCC2)C=C1)(NCC3=CC=NC=C3)=O
Molecular Formula
C18H22N2O2S
Molecular Weight
330.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Li-Huei Tsai, et al. Systems and assays for identifying pu.1 inhibitors. WO2021051016A1.|[2]Xie H, et al. Myeloid-derived MANF ameliorates ethanol-induced liver injury by enhancing microRNA-223 expression. J Gastroenterol. 2025 Jul;60 (7) :877-890.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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