PU.1-IN-1

PU.1-IN-1 is a potent PU.1 inhibitor with an IC50 of 2 nM. PU.1-IN-1 reduces rMANF-induced miR-223 expression. PU.1-IN-1 exhibits anti-inflammatory properties[1][2].

Product Specifications

CAS Number

[873588-27-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MicroRNA

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pu-1-in-1.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(C2CCCCC2)C=C1)(NCC3=CC=NC=C3)=O

Molecular Formula

C18H22N2O2S

Molecular Weight

330.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Li-Huei Tsai, et al. Systems and assays for identifying pu.1 inhibitors. WO2021051016A1.|[2]Xie H, et al. Myeloid-derived MANF ameliorates ethanol-induced liver injury by enhancing microRNA-223 expression. J Gastroenterol. 2025 Jul;60 (7) :877-890.