Fenoprofen (Calcium hydrate)

Fenoprofen (LILLY-53858) Calcium hydrate is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX) . Fenoprofen Calcium hydrate is a melanocortin receptors (MCRs) positive allosteric modulator (PAM) . Fenoprofen Calcium hydrate also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium hydrate has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis[1][2].

Product Specifications

CAS Number

[71720-56-4]

Product Name Alternative

LILLY-53858 (Calcium hydrate)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

COX; ERK; Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Fenoprofen-Calcium-hydrate.html

Purity

99.69

Solubility

DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic)

Smiles

CC(C([O-])=O)C1=CC(OC2=CC=CC=C2)=CC=C1.O.[0.5Ca2+]

Molecular Formula

C15H14O3.1/2Ca.H2O

Molecular Weight

279.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Yuan XC, et al. Fenoprofen-An Old Drug Rediscovered as a Biased Allosteric Enhancer for Melanocortin Receptors. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1066-1074. |[2]Montero-Melendez T, et al. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017 Apr;74 (7) :1335-1345.