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FMK 9a

FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay.

Product Specifications

CAS Number

1955550-51-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Atg4; Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/FMK_9a.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C=CC=C2)C2=CC=C1)N[C@H](C(NCC(CF)=O)=O)CC3=CC=CC=C3

Molecular Formula

C23H21FN2O3

Molecular Weight

392.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Qiu Z, et al. Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors. ACS Med Chem Lett. 2016 Jun 25;7 (8) :802-6.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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