PDE4-IN-18
PDE4-IN-18 (compound 1l) is a PDE4 inhibitor (IC50=1.55 μM) with anti-inflammatory activity. PDE4-IN-18 exerts anti-inflammatory effects by reducing excessive immune cell infiltration and intestinal membrane formation, as well as reducing the mRNA expression of pro-inflammatory cytokines (such as TNF-α and IL-6) in synovial tissue. PDE4-IN-18 can be used in the study of rheumatoid arthritis and psoriasis[1].
Product Specifications
UNSPSC
12352211
Target
Interleukin Related; Phosphodiesterase (PDE) ; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde4-in-18.html
Smiles
O=C1C2=CC(F)=CC=C2C(CC=C)=C(C3=CC(NS(=O)(C4=CC=CC=C4)=O)=CC=C3)N1
Molecular Formula
C24H19FN2O3S
Molecular Weight
434.48
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4
Frequently Asked Questions
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