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Deoxymannojirimycin hydrochloride

Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . Deoxymannojirimycin hydrochloride increases high mannose structures. Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer[1][2][3][4][5][6].

Product Specifications

CAS Number

84444-90-6

UNSPSC

12352200

Hazard Statement

H302-H312-H332

Target

HIV; Influenza Virus

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/deoxymannojirimycin-hydrochloride.html

Smiles

OC[C@@H]1[C@H]([C@@H]([C@@H](CN1)O)O)O

Molecular Formula

C6H13NO4

Molecular Weight

163.17

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Bagriaçik EU, et al. Glycosylation of native MHC class Ia molecules is required for recognition by allogeneic cytotoxic T lymphocytes. Glycobiology. 1996 Jun;6 (4) :413-21.|[2]Balzarini J. The alpha (1,2) -mannosidase I inhibitor Deoxymannojirimycin potentiates the antiviral activity of carbohydrate-binding agents against wild-type and mutant HIV-1 strains containing glycan deletions in gp120. FEBS Lett. 2007 May 15;581 (10) :2060-4.|[3]Lu Y, et al. Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721. Biochem Biophys Res Commun. 2006 May 26;344 (1) :221-5.|[4]Bischoff J, et al. The use of Deoxymannojirimycin to evaluate the role of various alpha-mannosidases in oligosaccharide processing in intact cells. J Biol Chem. 1986 Apr 5;261 (10) :4766-74.|[5]Ogier-Denis E, et al. Dual effect of Deoxymannojirimycin on the mannose uptake and on the N-glycan processing of the human colon cancer cell line HT-29. J Biol Chem. 1990 Apr 5;265 (10) :5366-9. |[6]F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275 (52) :41287-98.

Shipping Conditions

Room temperature

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Frequently Asked Questions

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