ALX-5407 (hydrochloride)
ALX-5407 ((R) -NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1].
Product Specifications
CAS Number
[200006-08-2]
Product Name Alternative
(R) -NFPS (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H410
Target
GlyT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/alx-5407-hydrochloride.html
Purity
98.36
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC=C([C@H](OC2=CC=C(C3=CC=CC=C3)C=C2)CCN(C)CC(O)=O)C=C1.[H]Cl
Molecular Formula
C24H25ClFNO3
Molecular Weight
429.91
Precautions
H302, H410
References & Citations
[1]Atkinson BN, et al. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60 (6) :1414-20.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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