ALX-5407 (hydrochloride)

ALX-5407 ((R) -NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1].

Product Specifications

CAS Number

[200006-08-2]

Product Name Alternative

(R) -NFPS (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H410

Target

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/alx-5407-hydrochloride.html

Purity

98.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC=C([C@H](OC2=CC=C(C3=CC=CC=C3)C=C2)CCN(C)CC(O)=O)C=C1.[H]Cl

Molecular Formula

C24H25ClFNO3

Molecular Weight

429.91

Precautions

H302, H410

References & Citations

[1]Atkinson BN, et al. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60 (6) :1414-20.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

Curated Selection

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