Doramapimod
Doramapimod is a protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. Doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK. Doramapimod also blocks proliferation of cells expressing BCR-ABL (T315I), with an IC50 of 2-3 µM.
Product Specifications
CAS Number
285983-48-4
Purity
98% by TLC NMR
Format
White to off-white solid.
Solubility
Soluble in DMSO (up to 50 mg/mL) or in Ethanol (up to 30 mg/mL)
Molecular Formula
C31H37N5O3
Shipping Conditions
-20°C
Storage Conditions
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Calculated Molecular Weight
527.66 Da
Curated Selection
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