FluoSite™ Anti-Nectin4 Antibody, FITC-Labeled

In contrast to other Nectins, which are found extensively in adult tissues, Nectin4 is abundant during fetal development but declines in adult life. Its expression, however, returns specifically in lung, breast, pancreas and ovarian cancers. It was shown that Nectin4 can modulate the expression of epithelial–mesenchymal transition related proteins via the PI3K (phosphoinositide 3-kinase) /AKT (protein kinase B) pathway. In addition, the recent study demonstrated that Nectin4 is a cancer specific TIGIT (T cell immunoreceptor with Ig and ITIM domains) ligand, and its expression is also associated with poor prognostic features, suggesting it could be an efficient target for cancer immunotherapy.

Fluorescein isothiocyanate (FITC) is a derivative of fluorescein and has an excitation and emission spectrum peak wavelengths of approximately 495 nm and 519 nm, causing it to fluoresce green.

At least 6 months at +4°C. Protect from prolonged exposure to light. DO NOT FREEZE. The antibody solution should be stored undiluted between +2°C and +8°C.