CD157 (BST1), His-Tag Recombinant
Recombinant human CD157, also known as BST1 (bone marrow stromal cell antigen 1), encompassing amino acids 29-292. This construct contains a C-terminal His-tag (6xHis) . The protein was affinity purified.
Product Specifications
Background
CD157, also known as BST1 (bone marrow stromal cell antigen-1) is a glycosylphosphatidylinositol (GPI) -anchored moleculewith the dual functions of receptor and β-NAD+metabolizing ectoenzyme, of the ADP-ribosyl cyclase family. This protein is expressed in the myeolomonocytic lineage (monocytes, neutrophils and others) and mesenchymal stem cells, mesothelial cells and many others. It plays a role in leukocyte adhesion, migration and diapedesis via its heparin-binding domains. Abnormalities in this protein are implicated in inflammatory disorders, such as RA (rheumatoid arthritis) . A potential therapeutic avenue for disorders where CD157 is implicated is the disruption of its interaction with ECM (extracellular matrix) proteins.
UniProt
Q10588
Tag
C-terminal His-Tag
Applications
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Purity
≥ 90%
Format
Aqueous buffer solution.
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at -80°C.
Calculated Molecular Weight
31 kDa + glycans
Formulation
8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Glycosylation
This protein runs at a higher MW by SDS-PAGE due to glycosylation.
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