Anti-GPRC5D Antibody
This anti-GPRC5D (G protein-coupled receptor class C group 5 member D) antibody is a purified, recombinant monoclonal antibody that recognizes human GPRC5D. The heavy chain construct includes a C-terminal Fc domain. This antibody has been tested for specific binding to human GPRC5D by flow cytometry.
Product Specifications
Background
GPRC5D (G protein-coupled receptor class C group 5 member D) is an orphan receptor of little-known function belonging to the large family of G protein-coupled receptors. The protein is highly expressed in malignant plasma cells such multiple myeloma and is now considered a therapeutic target for antibody-based treatment of multiple myeloma. For example, CAR-T cells and GPCR5DxCD3 bispecific antibodies resulted in promising outcomes at levels well tolerated by the patients.
UniProt
Q9NZD1
Applications
Useful for the flow cytometry analysis of human GPRC5D.
Purity
≥ 90%
Format
Aqueous buffer solution.
Shipping Conditions
-80°C
Storage Conditions
At least 12 months at -80°C.
Calculated Molecular Weight
Heavy Chain: 49 kDa + glycans; Light Chain: 24 kDa
Formulation
8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Glycosylation
This antibody runs at a higher MW by SDS-PAGE due to glycosylation.
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