Anti-CD8 Antibody, Biotin-Labeled

This purified recombinant antibody is a humanized mouse anti-CD8 a (cluster of differentiation 8 a) antibody. This antibody has a C-terminal Avi-Tag™ on its heavy chain. This antibody recognized human CD8.

Product Specifications

Background

CD8 is a co-receptor for the TCR (T cell receptor) in T cells, binding to MHC (major histocompatibility complex) class I proteins. CD8 is a typical marker of cytotoxic T cells and is involved in signaling. CD8 has two isoforms, a and b. CD8b recruits Lck (lymphocyte-specific protein tyrosine kinase) to the TCR-CD3 complex, and Lck phosphorylates multiple proteins involved in activation of CTLs (cytotoxic T-lymphocytes. It is thus critical for the lysis of cancer cells. Antibodies against CD8 are currently used in the clinic for the diagnostic of cancer, as in the case of crefmirlimab.

UniProt

P01731

Tag

C-terminal Avi-Tag™

Label

This antibody is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation was confirmed to be ≥90%.For more information on enzymatic biotinylation, please see ourTech Note.

Purity

≥ 90%

Format

Aqueous buffer solution.

Shipping Conditions

-80°C

Storage Conditions

At least 6 months at -80°C.

Calculated Molecular Weight

Heavy Chain: 51 kDa; Light Chain: 23 kDa + glycans

Formulation

8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol

Glycosylation

This antibody runs at a higher MW by SDS-PAGE due to glycosylation.

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