Anti-CD8 Antibody, Biotin-Labeled

CD8 is a co-receptor for the TCR (T cell receptor) in T cells, binding to MHC (major histocompatibility complex) class I proteins. CD8 is a typical marker of cytotoxic T cells and is involved in signaling. CD8 has two isoforms, a and b. CD8b recruits Lck (lymphocyte-specific protein tyrosine kinase) to the TCR-CD3 complex, and Lck phosphorylates multiple proteins involved in activation of CTLs (cytotoxic T-lymphocytes. It is thus critical for the lysis of cancer cells. Antibodies against CD8 are currently used in the clinic for the diagnostic of cancer, as in the case of crefmirlimab.

This antibody is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation was confirmed to be ≥90%.For more information on enzymatic biotinylation, please see ourTech Note.