Anti-CD4 Antibody, Biotin-Labeled

This purified recombinant antibody is a humanized mouse IgG4κ anti-CD4 (cluster of differentiation 4) antibody that selectively binds to CD4. Its sequence is similar to Ibalizumab. This antibody has a C-terminal Avi-Tag™ on its heavy chain. This antibody has been tested for specific binding to human CD4 in anin vitroELISA.

Product Specifications

Background

CD4 (cluster of differentiation 4) is part of the immunoglobulin superfamily, and it can be found in T-helper cells, monocytes, macrophages and dendritic cells. It is a co-receptor in the TCR (T-cell receptor), binding to MHC (major histocompatibility complex) class II molecules. CD4 binds to the tyrosine kinase Lck (lymphocyte-specific protein tyrosine kinase), which can phosphorylate the ITAM (immunoreceptor tyrosine activation motifs) domain of the CD3, activating CD3 related signaling. CD4 is a typical T cell marker of T helper cells, and it has been linked to cancer, autoimmune diseases such as vitiligo and type I diabetes. In addition, HIV-1 makes use of CD4 to trigger viral envelope protein conformational changes that allow cell infection. Ibalizumab, an anti-CD4 antibody, is currently used in the treatment of HIV, being considered a first-in-class medication. Further studies into CD4 and potential strategies around it may benefit patients and CD4 related diseases.

UniProt

P06332

Label

This antibody is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation is confirmed to be ≥90%.For more information on enzymatic biotinylation, please see ourTech Note.