Anti-CD123 Antibody, Biotin-Labeled
This anti-CD123 antibody is a purified, recombinant human monoclonal antibody that recognizes human CD123. This construct contains an Avi-tag™ in the middle of the Heavy Chain constant region. This recombinant antibody has been tested for specific binding to purified recombinant human CD123 by ELISA.
Product Specifications
Background
CD123, also known as interleukin 3 receptor alpha (IL3Ra), is a transmembrane protein found in pluripotent progenitor cells and involved in hematopoietic lineage differentiation. It can also be found in basophils, plasmacytoid dendritic cells and dendritic cells. CD123 is overexpressed on leukemic hematopoietic stem cells (HSCs), but not normal HSCs. It has been found in acute myeloid and B-lymphoid leukemias, blastic plasmacytoid dendritic neoplasms (BPDCN) and hairy cell leukemia. This expression profile makes CD123 an attractive target in cancer therapy. CAR-Ts and other therapies targeting CD123 are currently being evaluated in clinical trials.
UniProt
O75794
Label
This antibody is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation is confirmed to be >90%.For more information on enzymatic biotinylation, please see ourTech Note.
Applications
Useful for binding of CD123 in ELISA and in cellular assays.
Purity
≥ 90%
Format
Aqueous buffer solution.
Shipping Conditions
-80°C
Storage Conditions
At least 12 months at -80°C.
Calculated Molecular Weight
Heavy Chain: 52 kDa; Light Chain: 24 kDa + glycans
Formulation
8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Glycosylation
This antibody runs at a higher MW by SDS-PAGE due to glycosylation.
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