PCSK9 (D374Y) His-Avi-Tag, Biotin-Labeled Recombinant

PCSK9 (Proprotein convertase subtilisin/kexin type 9) functions as a negative regulator of hepatic low-density lipoprotein receptors (LDLRs) by binding to the LDLR ectodomain. The D374Y mutation is a gain of function mutation. The D374Y mutation is associated with hypercholesterolemia. This PCSK9 mutant is more potent at decreasing LDL uptake than wild-type PCSK9, most likely by increasing the binding affinity of PCSK9 for the LDLR. A deeper understanding of the function of this mutant protein and development of specific inhibitors may result in new therapeutic approaches for PCSK9 D374Y-linked diseases.

This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation was confirmed to be ≥90%.For more information on enzymatic biotinylation, please see ourTech Note.