Anti-PVRIG Neutralizing Antibody

This anti-PVRIG (Poliovirus receptor related immunoglobulin domain containing) antibody is a purified, recombinant human monoclonal antibody which recognizes human PVRIG. This recombinant antibody has been tested for specific binding to purified recombinant human PVRIG in an ELISA binding assay.

Product Specifications

Background

PVRIG, also known as Poliovirus receptor related immunoglobulin domain containing protein or CD112R, is a natural killer (NK) cell immune checkpoint receptor, and it is also found in CD8+T cells. PVRIG works as an inhibitory receptor and recognizes CD112 (also known as poliovirus receptor-related 2, PVRL2 or nectin-2) as its ligand. This binding results in lower responses of NK and T cells towards cancer cells. In T cells it inhibits the nuclear factor of activated T cells (NFAT) . Blocking the interaction between PVRIG and its ligand, for instance with an antibody directed towards PVRIG, represents a novel strategy in checkpoint blockade immunotherapy.

UniProt

Q6DKI7

Applications

Useful for binding and neutralization of PVRIG in ELISA and in cellular assays.

Purity

≥ 90%

Format

Aqueous buffer solution.

Shipping Conditions

-80°C

Storage Conditions

At least 12 months at -80°C.

Calculated Molecular Weight

Heavy Chain: 50 kDa; Ligh Chain: 24 kDa

Formulation

8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol