Anti-Mesothelin-Anti-CD3 Bispecific Antibody

Bispecific antibodies (BsMab) are chimeric antibodies with the ability to bind to two antigens and are typically created for immune cell activation, interfering with signal pathways or bringing proteins together. Mesothelin is a tumor differentiation antigen present in mesothelioma, ovarian cancer, pancreatic adenocarcinoma and others. CD3 (Cluster of Differentiation 3) is present in T cells and is involved in T cell activation. The ability to bring cancer cells to T cells allows for enhanced tumor cell killing and is a valuable tool in cancer immunotherapy.