Anti-Mesothelin-Anti-CD3 Bispecific Antibody
Anti-Mesothelin-Anti-CD3 Bispecific Antibidy is a Knot-in-Knob antibody that recognizes human mesothelin and CD3 proteins. This human bispecific antibody has been tested for specific binding affinity to mesothelin. The recombinant antibody was affinity purified.
Product Specifications
Background
Bispecific antibodies (BsMab) are chimeric antibodies with the ability to bind to two antigens and are typically created for immune cell activation, interfering with signal pathways or bringing proteins together. Mesothelin is a tumor differentiation antigen present in mesothelioma, ovarian cancer, pancreatic adenocarcinoma and others. CD3 (Cluster of Differentiation 3) is present in T cells and is involved in T cell activation. The ability to bring cancer cells to T cells allows for enhanced tumor cell killing and is a valuable tool in cancer immunotherapy.
UniProt
Q13421
Applications
Binding studies to mesothelin and CD3 in biochemical and cellular assays.
Purity
≥ 90%
Format
Aqueous buffer solution.
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at -80°C.
Calculated Molecular Weight
Heavy Chain: 49 kDa; Light Chain: 23 kDa
Formulation
8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol
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