Anti-HLA-DR Biotin-Labeled, Antibody

HLA-DR (human leukocyte antigen -DR isotype) is an MHC (major histocompatibility complex) class II protein and it serves as a ligand for the TCR (T cell receptor) when combined with an immunogenic peptide. Matching HLA isotypes is crucial in organ transplant, with HLA-DR being the main HLA isotype responsible for graft-versus host disease during the first 6 months post-transplant. A number of auto-immune diseases are linked to HLA-DR, including Crohn’s disease, lupus, and multiple sclerosis. HLA-DR is found in a subset of NK cells that combine properties from NK and dendritic cells. They are able to produce and release cytokines, degranulate and expand, but also present antigens to CD4+and CD8+T cells. The identification of HLA isotypes and understanding of the mechanisms of action of HLA-DR are thus crucial in medicine.

This antibody is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation is confirmed to be ≥90%.For more information on enzymatic biotinylation, please see ourTech Note.