Anti-PSMA, Biotin Label Antibody
Recombinant human anti-PSMA antibody recognizing human PSMA protein. This anti-PSMA antibody is a purified recombinant antibody, which contains an Avi-Tag™ and is biotinylated at the C-terminus of the heavy chain unit.
Product Specifications
Background
PSMA (prostate-specific membrane antigen, also known as Folate hydrolase 1, FOLH1), is highly expressed in prostate cells and is used as a diagnostic and prognostic indicator of prostate cancer. The enzyme has folate hydrolase and peptidase activity. It plays a role in prostate cancer progression through the PI3K-Akt and MAPK-ERK1/2 pathways. PSMA/FOLH1 is used in the clinic in PET (positron emission tomography) imaging of prostate cancer whereas radioactive analogs are used for the treatment of prostate cancer. PSMA is also expressed in other tumor types and in a few normal tissues, such as kidney. PSMA/FOLH1 is a target of CAR-T cells and bi-specific antibodies are currently under development for cancer therapy.
UniProt
Q04609
Label
This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation confirmed to be ≥90%.For more information on enzymatic biotinylation, please see ourTech Note.
Applications
Useful for studying the binding of PSMA in ELISA and in cellular assays.
Purity
≥ 90%
Format
Aqueous buffer solution.
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at -80°C.
Calculated Molecular Weight
Heavy Chain: 52 kDa; Light Chain: 23 kDa + glycans
Formulation
8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Glycosylation
This antibody runs at a higher MW by SDS-PAGE due to glycosylation.
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