Chemi-Verse™ PAK2 Kinase Assay Kit

PAK2, also known as P21 protein (Cdc42/Rac) -activated kinase 2, belongs to the group I of the PAK family of serine/threonine kinases. PAK2 can be found both in the cytosol and nucleus of most cells. It can be activated by cellular context dependent partners, and plays a role in several crucial cellular processes, such as cell proliferation and growth. PAK2, in particular, is linked to responses to caspase-mediated apoptosis. The molecule is cleaved in response to cell stress in a caspase-dependent manner, but its non-cleaved form seems to have anti-apoptotic effects. Amongst the PAK proteins, it is the most common protein mutated in cancer, particularly common in lung cancer. Once activated it can modulate the activity of proteins like c-Jun to stimulate melanoma cell growth, or caspase-7 to inhibit apoptosis in breast cancer cells.  Inhibition of PAK2 activity or expression has shown promising results in research studies and may represent a new therapeutic approach in cancer therapy.

Catalog #NameAmountStoragePAK2*5 µg-80°C793345x Kinase Buffer 11.5 ml-20°C79686500 µM ATP50 µl-20°CPAKtide, 1 mg/ml500 µl-20°C79696White 96-well plate1Room Temp*The concentration of the protein is lot-specific and will be indicated on the tube.

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