Idasanutlin
Potent MDM2 inhibitor with an IC50 = 6 nM in binding assay and 30 nM in cancer cell proliferation assay. Induces p53 stabilisation, cell cycle arrest and apoptosis in cancer cells expression wildtype p53. Displays inhibition of tumor growth in the SJSA1 tumor xenograft model. Also inhibits MDR-1 at high concentrations.
Product Specifications
CAS Number
1229705-06-9
Format
Solid
Molecular Formula
C31H29Cl2F2N3O4
Shipping Conditions
Room Temperature
Storage Conditions
At least 6 months at -20°C.
Calculated Molecular Weight
616.5 Da
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