GSK-6853
GSK-6853 is a potent and selective BRPF1 inhibitor. GSK-6853 exhibits >1600-fold selectivity for BRPF1 over other bromodomains (pIC50values by TR-FRET are 8.1,5.1/4.8 and 4.7/<4.3 for BRPF1, BRPF2/3 and BRD4 BD1/2, respectively) . The structural analog of GSK-6853, GSK-9311, serves as a good inactive control (125- and 185-fold reduced potency in cell-free and cell-based assays, respectively) .
Product Specifications
CAS Number
1910124-24-1
Format
Solid
Molecular Formula
C22H27N5O3
Shipping Conditions
Room Temperature
Storage Conditions
At least 6 months at -20°C.
Calculated Molecular Weight
409.5 Da
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