GSK-5959
GSK-5959 exhibits >100-fold selectivity for BRPF1 (IC50= 80 nM) over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3, which is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.
Product Specifications
CAS Number
901245-65-6
Format
Solid
Molecular Formula
C22H26N4O3
Shipping Conditions
Room Temperature
Storage Conditions
At least 6 months at -20°C.
Calculated Molecular Weight
394.5 Da
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