2′-Hydroxy-5′-methoxyacetophenone

2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inﬂammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC50s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity[1][2][3].

Product Specifications

CAS Number

[705-15-7]

UNSPSC

12352200

Hazard Statement

H315, H318, H335

Target

COX; NF-κB; NO Synthase; Parasite; Reactive Oxygen Species (ROS) ; TNF Receptor

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-hydroxy-5-methoxyacetophenone.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1=CC(OC)=CC=C1O)=O

Molecular Formula

C9H10O3

Molecular Weight

166.18

Precautions

H315, H318, H335

References & Citations

[1]Zhou J, et al. Discovery of 2-Ethoxy-5-isobutyramido-N-1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects. J Med Chem. 2024 Jan 11;67 (1) :213-233. |[2]Kim MG, Yang JY, Lee HS. Acaricidal potentials of active properties isolated from Cynanchum paniculatum and acaricidal changes by introducing functional radicals. J Agric Food Chem. 2013 Aug 7;61 (31) :7568-73.|[3]Li Wang et, al. Anti-ovarian cancer and collagenase, alpha amylase, and aldose reductase inhibition properties of 2′-Hydroxy-5′-methoxyacetophenone with molecular modeling studies. 2021 Sep.