CCT241533 (hydrochloride)
CCT241533 hydrochloride is a potent and selective CHK2 inhibitor with an IC50 of 3 nM and a Ki of 1.16 nM[1].
Product Specifications
CAS Number
1431697-96-9
UNSPSC
12352005
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CCT241533-hydrochloride.html
Purity
98.55
Solubility
DMSO : ≥ 100 mg/mL|H2O : 33.33 mg/mL (ultrasonic)
Smiles
[H]Cl.COC1=C(OC)C=C(C(N[C@H]2[C@H](C(C)(C)O)CNC2)=NC(C3=C(O)C=CC(F)=C3)=N4)C4=C1
Molecular Formula
C23H28ClFN4O4
Molecular Weight
478.94
References & Citations
[1]Anderson VE, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71 (2) :463-72.|[2]Caldwell JJ, et al. Structure-based design of potent and selective 2- (quinazolin-2-yl) phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54 (2) :580-90.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1; Chk2
Citation 01
J Cell Biol. 2021 Feb 1;220 (2) :e201911025.|Cell Death Differ. 2021 Jul;28 (7) :2060-2082.|Int J Mol Sci. 2022 Oct 14;23 (20) :12290.|J Chem Inf Model. 2017 Nov 27;57 (11) :2699-2706.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040630-500 1x 500 µL
Mucin 1 / EMA / Episialin / CD227 (VU-2G7), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400994-500 1x 500 µL
TNF alpha (J2D10), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details