CCT241533 (hydrochloride)

CCT241533 hydrochloride is a potent and selective CHK2 inhibitor with an IC50 of 3 nM and a Ki of 1.16 nM[1].

Product Specifications

CAS Number

[1431697-96-9]

UNSPSC

12352005

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CCT241533-hydrochloride.html

Purity

98.55

Solubility

DMSO : ≥ 100 mg/mL|H2O : 33.33 mg/mL (ultrasonic)

Smiles

[H]Cl.COC1=C(OC)C=C(C(N[C@H]2[C@H](C(C)(C)O)CNC2)=NC(C3=C(O)C=CC(F)=C3)=N4)C4=C1

Molecular Formula

C23H28ClFN4O4

Molecular Weight

478.94

References & Citations

[1]Anderson VE, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71 (2) :463-72.|[2]Caldwell JJ, et al. Structure-based design of potent and selective 2- (quinazolin-2-yl) phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54 (2) :580-90.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Chk1; Chk2

Citation 01

J Cell Biol. 2021 Feb 1;220 (2) :e201911025.|Cell Death Differ. 2021 Jul;28 (7) :2060-2082.|Int J Mol Sci. 2022 Oct 14;23 (20) :12290.|J Chem Inf Model. 2017 Nov 27;57 (11) :2699-2706.