JZP-MA-11
JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB) . [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP) [1].
Product Specifications
CAS Number
[1672691-50-7]
UNSPSC
12352005
Target
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jzp-ma-11.html
Concentration
10mM
Purity
99.26
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C=C1)N(C)C(OC2=NSN=C2N3CCCCC3)=O
Molecular Formula
C15H17FN4O2S
Molecular Weight
336.38
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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