DL-alpha-Tocopherol methoxypolyethylene glycol succinate

DL-alpha-Tocopherol methoxypolyethylene glycol succinate (TPGS-750-M) is an amphiphile, acts as a surfactant. DL-alpha-Tocopherol methoxypolyethylene glycol succinate has a positive effect on Suzuki-Miyaura cross coupling. DL-alpha-Tocopherol methoxypolyethylene glycol succinate increases the styrene titer. DL-alpha-Tocopherol methoxypolyethylene glycol succinate is used in the stability test of NPYM-modified drugs in biological fluids[1][2][3][4][5].

Product Specifications

CAS Number

[1309573-60-1]

Product Name Alternative

TPGS-750-M

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dl-alpha-tocopherol-methoxypolyethylene-glycol-succinate-solution.html

Concentration

20 mg/mL * 250 mL in Water

Purity

99.0

Solubility

H2O : ≥ 50 mg/mL

Smiles

CC1=C(CCC(CCCC(C)CCCC(C)CCCC(C)C)(C)O2)C2=C(C)C(C)=C1OC(CCC(OCCOC)=O)=O.[n]

Molecular Formula

(C2H4O) nC34H56O5

Precautions

H302, H315, H319, H335

References & Citations

[1]Lipshutz BH, et al. TPGS-750-M: a second-generation amphiphile for metal-catalyzed cross-couplings in water at room temperature. J Org Chem. 2011 Jun 3;76 (11) :4379-91.|[2]Cetin A, et al. Aqueous TPGS-750-M-mediated synthesis of pyrano [2, 3-c]-pyrazoles: a sustainable and efficient approach[J]. Research on Chemical Intermediates, 2024: 1-14.|[3]Wu B, et al. Merging biocatalysis, flow, and surfactant chemistry: innovative synthesis of an FXI (Factor XI) inhibitor[J]. Organic Process Research & Development, 2020, 24 (11) : 2780-2788.|[4]Ermini E, et al. A novel bioresponsive self-immolative spacer based on aza-quinone methide reactivity for the controlled release of thiols, phenols, amines, sulfonamides or amides. Chem Sci. 2024 Apr 2;15 (16) :6168-6177.|[5]Maaskant R V, et al. Merging whole‐cell biosynthesis of styrene and transition‐metal catalyzed derivatization reactions. ChemCatChem, 2021, 13 (6) : 1607-1613.