O-Desmethyltramadol (hydrochloride)
O-Desmethyltramadol (hydrochloride) is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its µ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme[1].
Product Specifications
CAS Number
[185453-02-5]
UNSPSC
12352005
Hazard Statement
H301, H336, H411
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/o-desmethyltramadol-hydrochloride.html
Purity
99.79
Solubility
H2O : ≥ 100 mg/mL
Smiles
OC1=CC=CC([C@]2(O)[C@@H](CN(C)C)CCCC2)=C1.Cl
Molecular Formula
C15H24ClNO2
Molecular Weight
285.81
Precautions
H301, H336, H411
References & Citations
[1]Lee J, et al. Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6. Drug Des Devel Ther. 2019;13:1751-1761.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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