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GSK3987

GSK3987 is a pan LXRα/β agonist with EC50s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation[1].

Product Specifications

CAS Number

264206-85-1

UNSPSC

12352005

Target

LXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/gsk3987.html

Purity

99.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C1=O)CC2=CC=CC=C2)C(NC3=CC=C(C=C3)OC)=C1C4=CC=CC=C4

Molecular Formula

C24H20N2O3

Molecular Weight

384.43

References & Citations

[1]HepG2 cells, ABCA1, SREBP-1c, cellular cholesterol, macrophages, triglyceride accumulation

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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