GSK3987
GSK3987 is a pan LXRα/β agonist with EC50s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation[1].
Product Specifications
CAS Number
264206-85-1
UNSPSC
12352005
Target
LXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gsk3987.html
Purity
99.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(C1=O)CC2=CC=CC=C2)C(NC3=CC=C(C=C3)OC)=C1C4=CC=CC=C4
Molecular Formula
C24H20N2O3
Molecular Weight
384.43
References & Citations
[1]HepG2 cells, ABCA1, SREBP-1c, cellular cholesterol, macrophages, triglyceride accumulation
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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