Umifenovir

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro[2]. Umifenovir shows anti-inflammatory activity[3].

Product Specifications

CAS Number

[131707-25-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CHIKV; Influenza Virus; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/umifenovir.html

Purity

98.04

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=C(CSC2=CC=CC=C2)N(C)C3=C1C(CN(C)C)=C(O)C(Br)=C3)OCC

Molecular Formula

C22H25BrN2O3S

Molecular Weight

477.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Julie Blaising, et al. Arbidol as a broad-spectrum antiviral: an update. Antiviral Res. 2014 Jul;107:84-94. doi: 10.1016/j.antiviral.2014.04.006. Epub 2014 Apr 24.|[2]Irina Leneva, et al. Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus. Viruses. 2021 Aug 23;13 (8) :1665.|[3]Yutao Wang, et al. Inhibition of the infectivity and inflammatory response of influenza virus by Arbidol hydrochloride in vitro and in vivo (mice and ferret) . Biomed Pharmacother. 2017 Jul;91:393-401.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Adv Sci (Weinh) . 2025 Oct 6:e10597.|J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2501743.|SSRN. 2024 Jan 26.|bioRxiv. 2020 Mar.|Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.|mBio. 2021 Feb 22;13 (1) :e0304421.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Signal Transduct Target Ther. 2021 Apr 24;6 (1) :165.|Viruses. 2019 Jul 20;11 (7) :665.|Viruses. 2021 Jul 23;13 (8) :1433.