7-Epi 10-desacetyl paclitaxel

7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM[1][2].

Product Specifications

CAS Number

[78454-17-8]

Product Name Alternative

7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel

UNSPSC

12352005

Hazard Statement

H351, H361

Target

ADC Payload

Type

Natural Products

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7-Epi_10-Desacetyl_Paclitaxel.html

Purity

99.76

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N[C@@H](C1=CC=CC=C1)[C@@H](O)C(O[C@H]2C[C@@](O)([C@@H](OC(C3=CC=CC=C3)=O)[C@@]4([H])[C@@]5(C)[C@H](O)C[C@]6([H])[C@@]4(OC(C)=O)CO6)C(C)(C)C([C@@H](O)C5=O)=C2C)=O)C7=CC=CC=C7

Molecular Formula

C45H49NO13

Molecular Weight

811.87

Precautions

H351, H361

References & Citations

[1]Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2) .|[2]Dang PH, et al.α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana. J Nat Prod. 2017 Apr 28;80 (4) :1087-1095.