4-Chlorokynurenine

4-Chlorokynurenine (4-Cl-KYN) is a prodrug of 7-Chlorokynurenic acid (NMDA receptor antagonist) (HY-100811) . 4-Chlorokynurenine has orally activity and blood-brain permeability. 4-Chlorokynurenine can reduce depressive symptoms and neurotoxicity. 4-Chlorokynurenine can be used for the research of neurological disease, such as depression and seizure[1][2][3].

Product Specifications

CAS Number

[153152-32-0]

Product Name Alternative

4-Cl-KYN; AV-101

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-chlorokynurenine.html

Purity

99.94

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC([C@@H](N)CC(C1=C(C=C(C=C1)Cl)N)=O)=O

Molecular Formula

C10H11ClN2O3

Molecular Weight

242.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Zanos P, et al. The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition. J Pharmacol Exp Ther. 2015 Oct;355 (1) :76-85.|[2]Wu HQ, et al. Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus. Eur J Pharmacol. 2000 Mar 3;390 (3) :267-74.|[3]Wu HQ, et al. L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat. Exp Neurol. 2002 Sep;177 (1) :222-32.