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Sapacitabine

Sapacitabine is an orally available nucleoside analog proagent that is structurally related to cytarabine.

Product Specifications

CAS Number

[151823-14-2]

Product Name Alternative

CS682; CYC682

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Sapacitabine.html

Purity

98.13

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(N=C(NC(CCCCCCCCCCCCCCC)=O)C=C1)N1[C@H]2[C@@H](C#N)[C@H](O)[C@@H](CO)O2

Molecular Formula

C26H42N4O5

Molecular Weight

490.64

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Serova M, et al. Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells. Br J Cancer. 2007 Sep 3;97 (5) :628-36.|[2]Green SR, et al. Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types. Br J Cancer. 2010 Oct 26;103 (9) :1391-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-16445/Sapacitabine-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-16445/Sapacitabine-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 3

Available Sizes

Curated Selection

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