Cy5-ProTx-II
Cy5-ProTx-II is a fluorescently labeled ProTx-II, a famous Nav1.7 blocker. The wild type ProTx-II blocks Nav1.7 with an IC50 value of around 300 pM, Nav1.2, Nav1.5 and Nav1.6 with IC50 values of 41 nM, 79 nM and 26 nM respectively. The Cy5-ProTx-II version developed by Smartox has potent Nav1.7 blocking activity. It was shown to fully block Nav1.7 at 100 nM concentration
Product Specifications
Specifications
Nav1.7 selective blocker
Target
Na channels
Sequence
YCQKWMWTCDSERKCCEGMVCRLWCKKKLW
Peptide Number
PTF002
Disulfide Bonds
Cys2-Cys16; Cys9-Cys21; Cys15-Cys25
N Terminal Sequence
Cy5
C Terminal Sequence
OH
Curated Selection
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