ATTO488-ProTx-II
ATTO488-ProTx-II is a fluorescently labeled ProTx-II, a famous Nav1.7 blocker. The wild type ProTx-II blocks Nav1.7 with an IC50 value of around 300 pM, Nav1.2, Nav1.5 and Nav1.6 with IC50 values of 41 nM, 79 nM and 26 nM respectively.ATTO488-ProTx-II has been tested and its biological activity has been validated.
Product Specifications
Specifications
Nav1.7 selective blocker
Target
Na channels
Sequence
YCQKWMWTCDSERKCCEGMVCRLWCKKKLW
Peptide Number
PTF004
Disulfide Bonds
Cys2-Cys16; Cys9-Cys21; Cys15-Cys25
N Terminal Sequence
ATTO488
C Terminal Sequence
OH
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