Huwentoxin-XVI
Huwentoxin-XVI is a 39 amino acids peptide that was discovered from the venom of the Chinese tarantula Ornithoctonus huwena. Huwentoxin-XVI was shown to be a potent blocker of HVA N-type calcium channels with an IC50 value of 60 nM in rat DRG. The blocking effect appears to be similar to that of ω-conotoxin-GVIA and ω-conotoxin-MVIIA. Neverthelss, Huwentoxin-XVI differs from GVIA and MVIIA thanks to its greater reversibility and its higher selectivity for N-type over P/Q type than MVIIA.
Product Specifications
Specifications
Selective blocker of N-type Ca2+ channels
Target
Ca channels
Sequence
CIGEGVPCDENDPRCCSGLVCLKPTLHGIWYKSYYCYKK
Peptide Number
HWT016
Disulfide Bonds
Cys1-Cys16; Cys8-Cys21; Cys15-Cys36
N Terminal Sequence
H
C Terminal Sequence
OH
Curated Selection
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