GaTx2
GaTx2 (gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus. GaTx2 is the most potent peptide inhibitor of ClC-2 (CLCN2) chloride channel ever described. Kd value is close to 20 pM. GaTx2slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABAC, Xenopus ClCa, Shaker B or Kv1.2 channels. Structurally, GaTx2 is composed of two β-strands and one α-helix.This peptide is also called Leiuropeptide II. Bears 89,93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.
Product Specifications
Specifications
Selective blocker of ClC2 (CLCN2) chloride channels
Target
Cl channels
Sequence
VSCEDCPDHCSTQKARAKCDNDKCVCEPI
Peptide Number
10GTX002
Disulfide Bonds
Cys3-Cys19; Cys6-Cys24; ; Cys10-Cys26
N Terminal Sequence
H
C Terminal Sequence
OH
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