ShK – Stichodactyla toxin
ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent potassium channels. It blocks Kv1.3 (KCNA3) potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) respectively with a Kd of 11 pM, 16 pM, 312 pM and 165 pM. Interestingly, it was also demonstrated that ShK potently inhibits the hKv3.2b channel with an IC50 value of approximately 0.6 nM
Product Specifications
Specifications
Selective blocker of Kv1.3
Target
K channels
Sequence
RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
Peptide Number
08SHK001
Disulfide Bonds
Cys3-Cys35; Cys12-Cys28; Cys17-Cys32
N Terminal Sequence
H
C Terminal Sequence
OH
CAS Number
165168-50-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6281185-02 5x 0.1 mL
CBX2, ID (CBX2, Chromobox protein homolog 2) (MaxLight 550)
Ask
View Details 