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Hm1a

Hm1a has been identified from the venom of the spider Heteroscodra maculata. Hm1a has been described as a potent and selective agonist of the voltage-gated sodium channel Nav1.1 with an EC value of 38 nM. Nav1.1 is expressed in the CNS and mutations are associated with several disorders such as epilespy or autism.Smartox Biotechnology is pleased to offer a synthetic and functionally active Hm1a dedicated to research laboratory use only.

Product Specifications

Specifications

Selective agonist of Nav1.1

Target

Na channels

Sequence

ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS

Peptide Number

HMA001

Disulfide Bonds

Cys2-Cys16; Cys9-Cys21; Cys15-Cys28

N Terminal Sequence

H

C Terminal Sequence

OH

Curated Selection

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