Hainantoxin-IV
Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spider Ornithoctonus hainana Liang (Selenocosmia hainana Liang) . It has been reported that this peptide is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs) . Hainantoxin-IV binds to TTX-S with an IC50value of 34 nM in adult rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by Hainantoxin-IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics.
Product Specifications
Specifications
Blocker of voltage-gated sodium channels
Target
Na channels
Sequence
ECLGFGKGCNPSNDQCCKSSNLVCSRKHRWCKYEI
Peptide Number
12HTX001
Disulfide Bonds
Cys2-Cys17; Cys9-Cys24; ; Cys16-Cys31
N Terminal Sequence
H
C Terminal Sequence
NH2
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