Agitoxin-2
Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated Kv1.3 and Kv1.1 channels. Agitoxin-2 inhibits Kv1.3 with an IC50 value of around 200 pM and Kv1.1 with an IC50 value of around 140 pM. This peptide toxin was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus.
Product Specifications
CAS Number
168147-41-9
Specifications
Blocker of Kv1.1 and Kv1.3 channels
Target
K channels
Sequence
GVPINVSCTGSPQCIKPCKDAGMRFGKCMNRKCHCTPK
Peptide Number
13AGI002
Disulfide Bonds
Cys8-Cys28; Cys14-Cys33; Cys18-Cys35
N Terminal Sequence
H
C Terminal Sequence
OH
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