ρ-Da1a (AdTx1)

AdTx1 (rho-Da1a – ρ-Da1a) is a 65 amino-acid peptide originally isolated from the venom of the green mamba, an African snake (Dendroaspis angusticep) . AdTx1 is stabilized by four disulfide bridges and belongs to the family of the three-finger-fold peptide. AdTx1 has subnanomolar affinity (K (i) = 0.35 nM) and high specificity for the human alpha (1A) -adrenoceptor subtype and is 1000 times more potent on this subtype than on other adrenoceptor subtypes. AdTx1 is a potent relaxant of smooth muscles.