μ-conotoxin-PIIIA
μ-Conotoxin PIIIA (mu-conotoxin PIIIA) is a conotoxin that has been isolated from the venom of the cone Conus purpurascens. μ-conotoxin PIIIA demonstrates a higher affinity for the mammalian muscle sodium channel Nav1.4 (IC50 ~ 44 nM) than for the CNS Nav1.2 subtype (IC50 ~ 640 nm) . μ-Conotoxin PIIIA blocks more irreversibly amphibian muscle sodium channels than mammalian ones.
Product Specifications
Specifications
Blocker of Nav1.4 channels
Target
Na channels
Sequence
RLCCGF (Hyp) KSCRSRQCK (Hyp) HRCC
Peptide Number
08CON006
Disulfide Bonds
Cys4-Cys16; Cys5-Cys21; Cys11-Cys22
N Terminal Sequence
PQ
C Terminal Sequence
NH2
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