Iberiotoxin
Iberiotoxin (IbTx) is a toxin that was originally isolated from Buthus tamulus scorpion venom. Iberiotoxin inhibits selectively the high conductance Ca2+-activated K+ channel (KCa1.1) at nanomolar concentrations (IC50 ~2 nM) . This toxin does not affect other types of calcium-dependent or voltage-dependent K+ channels. Iberiotoxin is a valuable tool to study specifically Maxi-K channels.
Product Specifications
CAS Number
129203-60-7
Specifications
Blocker of high conductance Ca2+-activated K+ channel
Target
K channels
Sequence
FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ
Peptide Number
12IBX001
Disulfide Bonds
Cys7-Cys28; Cys13-Cys33; Cys17-Cys35
N Terminal Sequence
PQ
C Terminal Sequence
OH
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