GsAF-1
GsAF-1 (also termed β-theraphotoxin-Gr1b, GsAF-I) was originally isolated from the venom of Grammostola rosea spider. GsAF-I peptide toxin is reported to block the following voltage-gated sodium channel isoforms: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with respective IC50 values of 0.4,0.6,1.3,0.3,1.2 and 0.04 µM. In addition, the toxin blocks the hERG1 isoform with an IC50 value of 4.8 µM.
Product Specifications
Specifications
Voltage-gated sodium channels blocker
Target
Na channels
Sequence
YCQKWLWTCDSERKCCEDMVCRLWCKKRL
Peptide Number
12GSF001
Disulfide Bonds
Cys2-Cys16; Cys9-Cys21; ; Cys15-Cys25
N Terminal Sequence
H
C Terminal Sequence
NH2
Curated Selection
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