Echistatin α1 isoform
Echistatin was originally purified from the venom of the viper Echis carinatus. Echistatin is a cyclic RGD peptide that inhibits platelet aggregation by inhibiting the glycoprotein IIb/IIIa complex receptor. Echistatin is a potent disintegrin that antagonize αVβ3 integrin and has been described to inhibit cell proliferation, migration, invasion, and adhesion of αVβ3 expressing cells.
Product Specifications
CAS Number
154303-05-6
Specifications
Antagonization of αVβ3 integrin. Inhibition of cell proliferation, migration, invasion, and adhesion of αVβ3 expressing cells.
Target
Integrins
Sequence
ECESGPCCRNCKFLKEGTICKRARGDDMDDYCNGKTCDCPRNPHKGPAT
Peptide Number
ECH001
Disulfide Bonds
Cys2-Cys11; Cys7-Cys32; Cys8-Cys37; Cys20-Cys39
N Terminal Sequence
H
C Terminal Sequence
OH
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