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Echistatin α1 isoform

Echistatin was originally purified from the venom of the viper Echis carinatus. Echistatin is a cyclic RGD peptide that inhibits platelet aggregation by inhibiting the glycoprotein IIb/IIIa complex receptor. Echistatin is a potent disintegrin that antagonize αVβ3 integrin and has been described to inhibit cell proliferation, migration, invasion, and adhesion of αVβ3 expressing cells.

Product Specifications

CAS Number

154303-05-6

Specifications

Antagonization of αVβ3 integrin. Inhibition of cell proliferation, migration, invasion, and adhesion of αVβ3 expressing cells.

Target

Integrins

Sequence

ECESGPCCRNCKFLKEGTICKRARGDDMDDYCNGKTCDCPRNPHKGPAT

Peptide Number

ECH001

Disulfide Bonds

Cys2-Cys11; Cys7-Cys32; Cys8-Cys37; Cys20-Cys39

N Terminal Sequence

H

C Terminal Sequence

OH

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